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An exclusive combination of probiotics and immune boosters New Probiotic Advantage Oral Sinus features the powerful combination of S. salivarius K12 and S. salivarius M18, the ONLY probiotics developed to colonize in the oral cavity. S. salivarius K12 and S. salivarius M18 produce BLIS (Bacteriocin-like Inhibitory Substances), which discourage the growth of undesirable bacteria. Research has found that the 10% of the population who naturally carry BLIS-producing strains of oral bacteria have significantly fewer sore throats. Probiotic Advantage Oral Sinus also includes L. reuteri to complete the probiotic power trio. L. reuteri has been found to maintain a normal level of healthy oral bacteria and to help prevent destructive bacteria from occupying the oral cavity.